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Inhibition of SLC12A3 reduces the magnitude in the focus gradient involving the epithelial cell and distal convoluted tubule, decreasing the reabsorption of h2o.

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Generally, sodium is reabsorbed into epithelial cells of your distal convoluted tubule and pumped into your basolateral interstitium by a sodium-potassium ATPase, making a focus gradient among the epithelial mobile along with the distal convoluted tubule that promotes the reabsorption of drinking water.

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